Ketorolac is a nonsteroidal antiinflammatory drug similar to ibuprofen, indomethacin, naproxen, and many others. Comparison of morphine, ketorolac, and their combination for. Comparison of iv, im and oral pharmacokinetics the pharmacokinetics of ketorolac tromethamine, following iv, im and oral doses of ketorolac tromethamine are compared in table 1. Incompatibilities are based on meeting any of the following criteria. The oral tablets are only indicated as continuation treatment after iv or im administration, if necessary. Compatibility of ketorolac tromethamine injection with common. Ketorolac tromethamine is available for intravenous iv or intramuscular im administration as. Stability of ketorolac tromethamine in iv solutions and waste. Ketorolac tromethamine eye drops acular, acuvail uses. Dec 16, 2016 for acute pain in the ed, parenteral ketorolac is generally administered as 30 mg iv or 60 mg im.
At the first sign of itching of throat or skin, stop using it. Oral ketorolac is only indicated as continuation treatment following iv or im dosing of ketorolac, if necessary. Compatibility and stability of ketorolac tromethamine and. The effect of intravenous ketorolac on opioid requirement. Ketorolac has similar analgesic efficacy at intravenous doses of 10, 15, and 30 mg, showing that intravenous ketorolac administered at the analgesic ceiling dose 10 mg provided effective pain relief to ed patients with moderate to severe pain without increased adverse effects. God forbid that anyone else has to go through what i went through because the nurses and doctors missed my alert on my paperwork.
Comparison of intravenous ketorolac at three singledose regimens for treating acute pain in the emergency department. You will receive your first doses of ketorolac by intravenous into a vein or intramuscular into a muscle injection in a hospital or medical office. A aripiprazole, caspofungin acetate, and ropivacaine hydrochloride. Home drugs a to z t to toradol consumer information print save or share toradol generic name. Compatibility of ketorolac tromethamine injection with common infusion fluids and administration sets. Ketorolac oral route, injection route precautions mayo clinic. Other analgesics were standardized between groups intravenous fentanyl in the recovery ward and oral codeine in the day stay unit.
Other drugs in this class include ibuprofen and naproxen naprosyn, aleve, but ketorolac is more effective than other nsaids in reducing pain from both inflammatory and noninflammatory causes. Vchphc revised june 2009 syringe compatibility chart use within 15 minutes atropine benztropine chlorpromazine codeine dimenhydrinate diphenhydramine droperidol fentanyl glycopyrrolate haloperidol hydromorphone hydroxyzine lorazepam meperidine methotrimeprazine metoclopramide midazolam morphine prochlorperazine. This reference contains standard dilutions including iv admixture drug concentration, infusion volumes, and infusion rates. It produces postoperative analgesia comparable to systemic opioids, but has a ceiling effect.
Our ketorolac products include tablets, ophthalmic solutions and injections. Ketorolac tromethamine injection, usp for intramuscular and intravenous use is available as. We have also added stability and compatibility information for three new drug products. Notably, the american association of pediatrics finds ketorolac compatible with breastfeeding. This information does not contain all possible interactions or adverse effects. The role of subcutaneous ketorolac for pain management. Its bioavailability and dosage are similar for im and iv administration after cesarean delivery, the efficacy of im. Study of whether 15 mg dose of ketorolac iv is as effective as a 30 mg dose. Stability of ketorolac tromethamine in iv solutions and. Ketorolac, a nonselective inhibitor of the cyclooxygenase cox enzyme, prevents the synthesis of prostaglandins and thromboxanes from arachidonic acid. Ketorolac eye drops is used to treat itching caused by seasonal allergic conjunctivitis an allergy that occurs at only certain times of the year.
Ketorolac works by reducing hormones that cause inflammation and pain in the body. Ketorolac may also be used for purposes not listed in this medication guide. Ketorolac tromethamine is a nonsteroidal antiinflammatory drug nsaid used for the shortterm relief of moderate to severe pain. This medicine is a topical nonsteroidal antiinflammatory drug nsaid. Nov 28, 2019 ketorolac tromethamine injection, usp is available for intravenous iv or intramuscular im administration as. Toradol is available for intravenous iv or intramuscular im administration as. Comparison of intravenous ketorolac at three singledose. In the eye prostaglandin is involved in inflammation, pain, and irritation due to allergies or mechanical injury. At 30 minutes, substantial pain reduction was demonstrated without any differences between the groups 95% confidence intervals 4. A few of the drugs that can potentially interact with ketorolac. A legend at the bottom of the page lists all compatibility types, and hovering your mouse over the icon will open a popup with the full. Ketorolac tromethamine monograph for professionals. Intravenous iv dilution ketorolac tromethamine toradol intravenous dilution protocols and pharmacology from globalrph. Toradol ketorolac side effects, dosage, interactions drugs.
Ketorolac dosing, indications, interactions, adverse. Although ketorolac is approved for im use, iv administration after orthopedic surgery has increased its use. It is also used to treat pain, burning, and inflammation of the eye following cataract surgery or corneal refractive surgery. Ketorolac tromethamine tablets ketorolac tromethamine dose. Ketorolac reduces the production of prostaglandins, chemicals that. Each monograph contains stability data, administration guidelines, and methods of preparation. Ketorolac tromethamine toradol, a nonsteroidal antiinflammatory drug nsaid, is commonly used alone or in combination with other analgesics for pain management in both hospital inpatients and outpatients. Ketorolac is a nonsteroidal antiinflammatory drug nsaid. Therapy should always be initiated with iv or im dosing of ketorolac tromethamine, and toradol ketorolac tromethamine oral is to be used only as. Ketorolac is used shortterm 5 days or less to treat moderate to severe pain.
Iv drug compatibility chart k ketorolac tromethamine alteplase activase, rtpa amiodarone cordarone argatroban atropine calcium chloride diltiazem cardizem dobutamine dobutrex dopamine epinephrine adrenalin esmolol brevibloc furosemide lasix heparin insulin regular lidocaine xylocaine lorazepam ativan magnesium sulfate. Toradol is in a group of drugs called nonsteroidal antiinflammatory drugs nsaids. Although the onset of action of ketorolac and morphine is similar, ketorolac has a longer halflife, 5ampersandnumbersignx020. Reviewed toradol on 832019 as with any medications used for pain, this one is a favorite in ers and by some surgeons. Study of whether 15 mg dose of ketorolac iv is as effective. Comparison of morphine, ketorolac, and their combination. Toradol im injection, iv injection information from. Dailymed ketorolac tromethamine injection, solution. It is typically given before or after medical procedures or after surgery. Additive compatibility drugs in syringe compatibility. Ketorolac dosing, indications, interactions, adverse effects, and more. Limit duration of use so the total combined duration of oral and parenteral ketorolac. Toradol ketorolac is used to relieve shortterm, moderatetosevere pain in adults. Prostaglandins have many effects in the body including their role in pain and inflammation.
The smarter search functionality includes a single search box on. Stability and compatibility of the mixture of tramadol. Last, we administered the medication intravenously, and many studies from which the nnts were obtained used the intramuscular route. The opioidsparing effects of intravenous ketorolac as an adjuvant. Iv compatibility results are organized onto separate tabs, so that you can quickly access the route or method in which you are interested. Ketorolac tromethamine and morphine hydrochloride were mixed together in 0. Shortening the recommended dosing intervals may result in increased frequency and severity of adverse reactions. Trissel, fashp, 2010, american society of healthsystem pharmacists.
Ketorolac is used for the shortterm relief of moderately severe pain and should not be used for longer than 5 days, for mild pain, or for pain from chronic longterm conditions. Parenteral ketorolac has been used concomitantly with opiate agonist analgesics e. Ketorolac is used for the shortterm treatment of moderate to severe pain. Ns or d5w preferred diluent for acetaminophen overdose acyclovir.
Favorites subscribe to favorite the drugs you use most often for quick access. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. There are no stability data for periods beyond 48 h for ketorolac diluted in iv fluids. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Drug interactions with ketorolac can increase your risk of serious side effects, make some drugs less effective, and cause your body to metabolize the drugs differently than intended, among other things. Ketorolac tromethamine is prescribed for the treatment of allergic conjunctivitis pink eye, post operative inflammation pain, burning, and stinging after eye surgery such as cataract surgery or corneal. See what others have said about ketorolac, including the effectiveness, ease of use and side effects. Syntex, dee why, new south wales is a pyrrole acetic acid nonsteroidal antiinflammatory drug nsaid designed for parenteral administration. The iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Jan 26, 2006 ketorolac tromethamine is available for intravenous iv or intramuscular im administration as. Feb 20, 2015 patients received either ketorolac 10. Ketorolac tromethamine acular, acular ls, acuvail is a nsaid medication similar to other nsaids like ibuprophen, naproxen, and many others. Oct 29, 2010 study of whether 15 mg dose of ketorolac iv is as effective as a 30 mg dose.
Substitutes and alternatives to toradol ketorolac for uses like pain, postoperative ocular pain and inflammation after eye surgery and ocular itching. The compatibility of ketorolac tromethamine injection with commonly used i. Check out these bestsellers and special offers on books and newsletters from mayo clinic. The combined duration of use of parenteral, oral, and nasal ketorolac should not exceed 5 days. Listing a study does not mean it has been evaluated by the u. Toradol ketorolac side effects, dosage, interactions. Oral ketorolac therapy is only indicated as continuation therapy to iv im therapy. Compatibility is denoted by an icon and simple description. Our online store features the generic drug from several different manufacturers such as hospira, sun pharmaceutical industries, teva and wockhardt pharmaceuticals. It is usually used before or after medical procedures or after surgery. Sold under names such as toradol and ketorolac tromethamine tables, it is most often used to treat pain following a procedure, but it can also be used to relieve back pain, cancer pain, and pain caused by kidney stones.
The ceiling effect of iv ketorolac the pharmertoxguy. Ketorolac is a member of a class of drugs called nonsteroidal antiinflammatory drugs that are used for treating inflammation and pain. For acute pain in the ed, parenteral ketorolac is generally administered as 30 mg iv or 60 mg im. Compatibility of ketorolac tromethamine injection with. Systemic use of ketorolac is only indicated for the shortterm management of moderately severe acute pain that requires analgesia at the opioid level. Intravenous admixtures preparation and infusion guidelines. Ketorolac tromethamine injection, usp is available for intravenous iv or intramuscular im administration as. A also included in this update are compatibility information for cefepime, ganciclovir, ketamine, ketorolac, and nesiritide. Ketorolac dosing, indications, interactions, adverse effects. Jan 07, 2019 the combined duration of use of parenteral, oral, and nasal ketorolac should not exceed 5 days.
Comparison of iv, im and oral pharmacokinetics the pharmacokinetics of ketorolac tromethamine, following iv and im doses of ketorolac tromethamine and oral doses of toradol, are compared in table 1. Ketorolac systemic drug monograph pediatric care online. For solution and drug compatibility information, see compatibility under stability. Food can decrease peak and delay timetopeak concentrations. Ketorolac has mild interactions with at least 78 different drugs.
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